Czech Innovation Against Alzheimer’s: H2 Global Group Enters a Key Growth Phase

Czech Innovation Against Alzheimer’s: H2 Global Group Enters a Key Growth Phase

H2 Global Group, together with its subsidiary H2 Medical Technologies, has entered a decisive growth stage following strong recognition at LSI Europe 2025 in London. The group presented its breakthrough approach to preventing and treating neurodegenerative diseases, including Alzheimer’s, confirming its position among global leaders in the MedTech and HealthTech sectors.

At the core of this innovation is a prototype medical device for controlled hydrogen therapy, developed by H2 Medical Technologies. The device is designed for patients with mild cognitive impairment, a condition that often precedes Alzheimer’s. Non-invasive and suitable for both clinical and home use, it is based on a patented method pioneered by a Japanese team led by Professor Shigeo Ohta, co-owner of H2 Global Group. Research indicates that molecular hydrogen can protect brain cells, slow inflammation, and support neuronal metabolism and connectivity.

“Hydrogen is the smallest molecule in the universe, yet it can protect our most valuable assets – memory and independence,” explains Prof. Ohta.

Group founder David Maršálek, who has been developing hydrogen technologies since 2011, adds: “Our mission is to launch the world’s first hydrogen-based medical device for Alzheimer’s prevention and therapy support. With strong scientific evidence, patent protection, and an experienced team, we are positioned to succeed.”

Between 2021 and 2025, H2 Global Group raised over $18M in Seed funding, built a network of 20,000 end-customers and 50+ B2B partners, and exceeded revenues of circa $7.4M. Current transactions value the group at circa $77M.

Now entering Series A, the group plans to raise $25–30 million to fund global expansion into Europe, the U.S., the Middle East, and Africa, complete clinical trials, and secure EU and FDA registrations. Revenue projections forecast growth to nearly $48M by 2029.

The portfolio extends beyond the medical device. H2 Medical Technologies supplies hydrogen generators and therapeutic systems to spas, sports clubs, physiotherapy practices or dental clinics. Its solutions are also approved for veterinary use. In parallel, H2 Pharm develops consumer products such as H2 Premium Water®, H2 Brain®, H2 Forte®, and H2 Dent Care®, which are commercially successful and distributed via e-commerce and a B2B network.

“Such opportunities are rare,” concludes Maršálek. “When future textbooks are written, our investors will say: I was there. Hydrogen is not only energy source but a molecule of lifeconnecting the world. Invest in Hydrogen!”

Source: ap.news.com

Czech MedTech Startup H2 Medical Technologies Unveils World’s First Patented Hydrogen-Based Therapy with the Potential to Target Alzheimer’s Disease

Czech MedTech Startup H2 Medical Technologies Unveils World’s First Patented Hydrogen-Based Therapy with the Potential to Target Alzheimer’s Disease

H2 Medical Technologies, part of the H2 Global Group, has developed the world’s first functional hydrogen-based therapy medical device prototype for clinical trials — aimed at both preventing and treating Alzheimer’s disease.

Today, more than 6.5 million Americans and 50 million people worldwide are living with Alzheimer’s and other forms of dementia. According to the World Health Organization, this number could triple by 2050, placing an immense burden on families and healthcare systems. Despite decades of research, no effective solution has been found — until now.

“This is not another experiment — it is the first technology in the world with the potential to prevent Alzheimer’s disease before it even starts, while supporting those already affected,” says David Marsalek, founder and CEO of H2 Global Group. The company believes its effectiveness will be further confirmed in an upcoming new clinical trial. “Our mission is clear: to turn decades of research into real hope for millions of families around the world. We are part of a strong vision of a society where hydrogen is the molecule of life that connects the world.”

From the Lab to the Global Stage

H2 Global Group will present this breakthrough at LSI Europe 2025 in London, one of the world’s most prestigious MedTech and HealthTech conferences. The project builds on 30+ years of research and patents developed with Professor Shigeo Ohta, a global leader in molecular hydrogen science and co-founder of H2 Global Group.

More Than Medicine: A New Era of Brain Health

While the immediate focus is Alzheimer’s, potential applications extend to neurological disorders, brain regeneration, and healthy aging.

Alongside its medical device, H2 Global Group has launched consumer products such as H2 Premium Water® and H2 Brain®, a world-first two-phase dietary supplement that stimulates molecular hydrogen production through the gut microbiome. The company is also the only certified global manufacturer authorized to use hydrogen-based medical devices in veterinary medicine.

Today, its hydrogen-based solutions are already being adopted by wellness centers, rehabilitation clinics, dental practices, and elite sports organizations across Europe — underscoring the broad potential of the technology.

An Opportunity for Visionary Investors

Until now, the project has been funded primarily by Czech investors. H2 Global Group is now opening the door to U.S. and global partners at a critical growth stage, with EU registration underway and FDA approval next on the horizon — unlocking the world’s largest healthcare market.

The global Alzheimer’s therapeutics market is projected to exceed $20 billion by 2030, with dementia-related costs already surpassing $1 trillion annually. Positioned as the only functional hydrogen-based therapy of its kind, H2 Global Group offers investors a rare first-mover advantage in one of the most urgent and lucrative markets of our time.

H2 Brain®: Innovative Support for Mental Well-being at the Cellular Level

H2 Brain®: Innovative Support for Mental Well-being at the Cellular Level

H2 Vibe proudly introduces H2 Brain®, an innovative food supplement developed to support mental wellbeing and cognitive performance – both during the day and at night. This unique two-phase formulation respects the body’s natural circadian rhythm and is carefully tailored to meet the brain’s changing needs throughout the day.

Today’s fast-paced lifestyle, combined with a lack of physical activity and chronic stress, is taking a toll on our mental health. “People today live under immense pressure, which often results in poor sleep quality and a general sense of mental unease,” explains Viktória Procházková, CEO of H2 Global Group. “At the same time, data indicates a growing prevalence of neurological disorders, which motivated us to develop a comprehensive solution aimed at supporting cognitive function and emotional balance.”

For nearly a year, the Czech company H2 Global Group fine-tuned the formula to perfection – resulting in H2 Brain®, a two-phase supplement designed to meet the brain’s essential needs and promote mental clarity and emotional resilience. “Throughout the development of H2 Brain®, we paid close attention to the bioavailability and synergistic interactions of each ingredient to achieve maximum efficacy at the cellular level,” adds PharmDr. Milan Krajíček, Head of Research and Production at H2 Pharm.

Targeted Support – Day and Night

H2 Brain® has been developed as a two-phase system to address the brain’s distinct daytime and nighttime needs. The morning tablet is focused on enhancing concentration and cognitive performance throughout the day. It includes Baikal skullcap extract, astaxanthin, and selenium with sustained release properties. The evening tablet, by contrast, is formulated to encourage mental relaxation and restorative sleep, with ingredients such as taurine, B vitamins, and ginkgo biloba.

H2 Brain® also features the patented HydrogenIQ complex, which naturally supports the production of molecular hydrogen. As the smallest molecule in the universe, molecular hydrogen is currently being explored for its unique ability to cross the blood–brain barrier and reach brain cells. Research suggests it may play a beneficial role in promoting cellular regeneration and protecting neurons against oxidative stress.

For Students, Professionals, Parents and Seniors

H2 Brain® is designed for a wide range of individuals – from students seeking to boost focus during intensive study, to professionals and parents managing high cognitive loads, to older adults looking to support mental clarity and cognitive longevity. “Our aim with H2 Brain® was to create a supplement that actively supports brain function and contributes to long-term mental wellbeing,” concludes Krajíček.

According to the World Health Organization (WHO), approximately 55 million people worldwide are currently living with dementia, with around 10 million new cases diagnosed each year. Alzheimer’s disease accounts for 60–70% of these cases. By 2050, the global number of people affected by dementia is expected to rise to 139 million. This alarming trend highlights the urgent need for proactive measures to support brain health from midlife onwards.

“Hydrogen protects athletes’ bodies from injury!”

“Hydrogen protects athletes’ bodies from injury!”

Former national athlete and current director and coach of the Ostrava Individual Sports Centre Tatiana Netoličková is a fan of hydrogen technology. That is why she recommends H2 Health&Beauty products to her charges, because she wants the best not only for their performance, but especially for their recovery and as injury prevention.

You are the director of the Individual Sports Centre Ostrava. Could you introduce the centre, who it is for and how it works?
I have been the director of CISO for 17 years. I try to help out in training as well. We include in our centre representatives from our region, not only athletes, but we have 26 sports included, including disabled athletes. We currently have 80 athletes with us, looked after by 50 coaches. Without the financial support of the region, the City of Ostrava and regional sponsors, including H2 Global Group, we would not be able to function and we are grateful to all of them.

You prepare young promising athletes. How does the athletic training of today’s talents differ from yours when you were competing?
This question cannot be answered unequivocally, because each of the 26 sports has a specific preparation, and in athletics in particular, not everyone trains according to one standard, it is strictly individual. I just think that some coaches lack a bit of patience, they want to have successful charges too early and train a lot at an early age.

How’s today’s preparation looking? Apart from training, does it include, for example, physiotherapy or some psychological hygiene of athletes, do you also deal with the diet and lifestyle of your charges?
Yes, we try to keep them healthy first and foremost, we insist on annual stress tests at the Sports Medicine Department, where they take care of our “sheep” (laughs). Many of them have already learned to deal with healthy nutrition on their own, they understand that they can’t do without it and it affects their performance a lot. We have guided some of them to this through the seminars we also organize in our camps. Of course, recovery, mental coach, supplementation… these are things that we can’t imagine the training process without nowadays.
You and CISO athletes use products with molecular hydrogen. How do you evaluate its effects?
The molecular hydrogen from H2 Health&Beauty products has been used by CISO athletes for several years because it is beneficial for their demanding training. These exceptional products reach all parts of the body as an antioxidant, eliminate fatigue, break down lactic acid after a hard workout and help the body recover faster. But it is there for us especially as a preventive element, it protects the athletes’ body from injury, so they can perform at their best and can fulfil their dreams.

You and CISO athletes use products with molecular hydrogen. How do you evaluate its effects?
The molecular hydrogen from H2 Health&Beauty products has been used by CISO athletes for several years because it is beneficial for their demanding training. These exceptional products reach all parts of the body as an antioxidant, eliminate fatigue, break down lactic acid after a hard workout and help the body recover faster. But it is there for us especially as a preventive element, it protects the athletes’ body from injury, so they can perform at their best and can fulfil their dreams.

Sport and regeneration: Hydrogen is the trend for 2024

Sport and regeneration: Hydrogen is the trend for 2024

Physical exercise is the foundation of a healthy lifestyle, but effective recovery is also the key to optimal results. In 2024, we’re seeing new trends shaping the ways athletes recover their bodies after a tough workout. One of the main topics receiving increased attention is molecular hydrogen.

Molecular hydrogen: A new dimension in regeneration
More and more athletes and fitness enthusiasts are turning to molecular hydrogen as part of their recovery routine. Studies suggest that hydrogen may have significant antioxidant and anti-inflammatory properties that can help improve muscle recovery and reduce fatigue. This innovative method uses the properties of hydrogen to promote rapid recovery of the body after a strenuous workout or exercise. Hydrogen therapy consists of three main elements: bathing, drinking hydrogen water and inhalation.

OLYMPIC CHAMPION ALEŠ VALENTA HAS BEEN USING THE EFFECTS OF MOLECULAR HYDROGEN FOR SEVERAL YEARS. PHOTO: ALEŠ VALENTA

Most often, molecular hydrogen is administered in the form of hydrogen-enriched water, which is an easily acceptable way to incorporate the rich recovery benefits into an athlete’s daily routine. Hydrogen baths in a special H2 SPA tub have become a popular method for fast recovery for athletes. The tub allows you to provide a unique, rejuvenating and regenerative experience. It includes a high-pressure generator that creates nanobubbles filled with hydrogen. This allows hydrogen to enter the body where it can help reduce inflammation, relieve muscle tension and improve circulation.

A proponent of regenerative hydrogen therapy is, for example, the Olympic champion in acrobatics on skis Aleš Valenta, who uses products from the Czech hydrogen leader H2 World Health and Beauty. “Even in my 50s, I try to do sports every day. I play hockey, I ride my bike, I ski. I use molecular hydrogen as a daily supplement to stay fit. I take Forte in the morning, Slim&Fit after lunch and Dent Care in the evening. Of course, I wash it all down with water enriched with molecular hydrogen from the generator.”

Hydrogen regeneration therapy represents a new and innovative approach to rapid recovery after physical exertion. This method combines relaxation, hydration and the direct action of antioxidants on the body, which can help athletes achieve optimal performance and maintain a balanced and healthy recovery. With the growing interest in hydrogen therapy, it is expected to become an increasingly common part of training plans and recovery strategies for athletes around the world.

Ice water regeneration
One of the traditional and increasingly popular approaches to recovery after strenuous athletic performance is the use of ice water. Also known as cryotherapy, this method uses the cold action of water to speed muscle recovery and reduce inflammation.

How does it work? When you immerse yourself in ice water, the surface tissues are rapidly cooled to a temperature of around 10 degrees Celsius. This process causes a reflex contraction of blood vessels, which reduces blood flow to the affected areas and helps to reduce inflammation and swelling.

Yoga and meditation
Nowadays, with sport becoming an increasingly important part of lifestyle, new and effective ways are being sought to maximise recovery and restore the body after a tough workout. Trends for 2024 include integrating yoga and meditation into athletes’ recovery routines. These ancient practices offer many benefits to help the body recover and enhance mental and physical well-being.

Yoga is a comprehensive system of exercise that combines physical postures (asanas), breathing (pranayama) and meditation. The asanas of yoga not only help open and stretch muscles, improve flexibility and range of motion, but also strengthen the muscles of the center of the body, which can contribute to better stability and injury prevention. But yoga in particular should help reduce stress and tension levels, which has a positive effect on overall well-being and mental health. Meditation is then thought to result in calming the mind, improving sleep, increasing concentration and increasing overall mental resilience.

A personalised approach to recovery
Another trend in post-sport recovery is the emphasis on an individual approach. Each athlete has unique needs and recovery strategies should be tailored to specific goals, exercise intensity and personal health status.

This means that recovery techniques may include other recovery methods such as massage, sauna, stretching, cold baths or relaxation exercises, among others.

Technologies that promote regeneration
In 2024, we also see the rise of technologies aimed at supporting regeneration. Electrical stimulation devices, compression garments and massage equipment are increasingly popular options for athletes looking for a quick and effective way to recover their bodies after a tough workout.

Recovery after sport is a key element of any training plan. In 2024, we are seeing new trends that include molecular hydrogen as a potential means to promote recovery, a personalized approach to body recovery and the use of modern technology. It is important that each athlete finds their own recovery regime to help them achieve optimal results and keep their body fit.

H2 Global Group
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