Molecular hydrogen streamlines care for rheumatic patients

Molecular hydrogen streamlines care for rheumatic patients

Hydrogen Inhalation Improves Physical Fitness in Patients with Rheumatic Diseases, New Czech Study Shows. A ground-breaking study conducted over nearly two years at Teplice nad Bečvou Spa has shown that molecular hydrogen inhalation significantly improves physical fitness in patients with rheumatic conditions. The research, carried out in collaboration with experts from Palacký University Olomouc, involved 24 patients divided into experimental and placebo groups. Results from the hydrogen group were 50% better than those of the placebo group.

Patients who inhaled hydrogen for 15 consecutive days showed notable improvements in the six-minute walk test, as well as increased comfort during movement and better tolerance to physical exertion and muscle fatigue.

A Controlled, Double-Blind Clinical Study

This prospective, randomised, double-blind, placebo-controlled study aimed to verify the effects of molecular hydrogen inhalation on enhancing physical performance, reducing perceived exertion, and improving autonomic cardiac regulation in patients undergoing standard spa treatment, which included traditional procedures and guided physical activity.

The research was led by Assoc. Prof. Michal Botek, Ph.D., of the Faculty of Physical Culture at Palacký University, which has been researching molecular hydrogen for over eight years. H2 Global Group provided technical support for the study, supplying the hydrogen generators used by participants.

“Our results suggest that hydrogen inhalation leads to a significant improvement in functional status in patients with rheumatic diseases,” said Dr Botek.
“Those who underwent the 15-day treatment showed an average improvement of 93 metres in the six-minute walking test—a 50% increase compared to the placebo group. Participants also reported lower perceived effort during walking and improved autonomic nervous system function.”

Spa Medicine Enhanced by Hydrogen Innovation

“Hydrogen therapy allows us to offer a more advanced form of rehabilitation—one that not only improves fitness but also enhances recovery and overall well-being,” said MUDr. Gabriela Hanslianová, Head Physician at Teplice nad Bečvou Spa.
“The results of the study motivate us to expand the use of this innovative method within spa care.”

Teplice Spa has been using molecular hydrogen since 2020. The current study builds on previous research by Dr Botek, including a 2022 publication demonstrating the beneficial effects of hydrogen inhalation on patients recovering from COVID-19.

Currently, his team is conducting further research at Bludov Spa, examining the metabolic effects of drinking hydrogen-rich water in adolescents with obesity undergoing a four-week programme involving exercise and caloric restriction.

“We’re continuously exploring the broad therapeutic potential of molecular hydrogen, from respiratory parameters to metabolism and physical performance,” says Dr Botek. “We believe its benefits for both spa and exercise-based therapies are far greater than currently realised.”

Hydrogen as a Targeted Antioxidant

“Molecular hydrogen acts as a selective antioxidant that protects cells from oxidative stress and inflammation,” explains Professor Shigeo Ohta, Ph.D., a globally recognised expert in molecular hydrogen and Director of Science & Research at H2 Global Group.
“Its properties make it a powerful tool for reducing chronic inflammation and supporting faster recovery in these types of conditions.”

For the purposes of the study, H2 Global Group provided molecular hydrogen generators, which patients in the experimental group used daily for 15 days. Participants inhaled hydrogen via a nasal cannula for 60 minutes each day, while the placebo group inhaled ambient air. The double-blind protocol ensured that neither the patients nor the spa personnel administering the treatment knew who was receiving hydrogen and who was not—ensuring objective and unbiased results.

Unlocking New Possibilities in Rehabilitation

This study opens up new possibilities for the use of molecular hydrogen in therapeutic protocols, whether through inhalation or hydrogen-enriched water, across a broader range of medical indications. With growing scientific evidence, hydrogen therapy is emerging as a safe and effective tool to support regeneration, mobility, and systemic balance—both in spa environments and beyond.

Hydrogen against children’s obesity

Hydrogen against children’s obesity

A unique research project has commenced at Bludov Spa, investigating the potential of molecular hydrogen to support weight loss in obese children and adolescents. This innovative study, conducted in collaboration with the Faculty of Physical Culture at Palacký University Olomouc and the H2 Global Group, could represent a major breakthrough in adolescent obesity treatment. The research is being carried out as a double-blind experiment, ensuring maximum objectivity.

Obesity affects approximately 20% of the Czech population and over 13% of the global population, making it a serious worldwide public health concern.

“The idea to examine the effect of molecular hydrogen on weight loss in obese children arose from growing interest in its therapeutic properties,” explains Mgr. Darja Supíková of the Olomouc University research team.
“Molecular hydrogen has antioxidant and anti-inflammatory effects, which may play an important role in regulating metabolism and reducing oxidative stress—both of which are factors associated with obesity.”

Double-Blind Clinical Trial with Hydrogen-Enriched Water

The study is being conducted on a sample of 60 adolescents aged 13 to 18, each of whom consumes hydrogen-enriched water three times daily over the course of four weeks—the standard duration of spa-based obesity treatment.

The H2 Global Group has provided the bottled water for the study in two variants: half of the cans contain molecular hydrogen, while the other half contain plain drinking water. Since neither the patients nor the spa staff know which variant they are administering, the trial meets double-blind clinical standards.

Research leader Mgr. Darja Supíková also prepared regular exercise classes for the research participants. Photo source: Darja Supíková

Collaboration Rooted in Health

According to Assoc. Prof. Michal Botek, who is leading the study, a memorandum of cooperation was signed prior to the trial between Palacký University, Bludov Spa, and H2 Global Group, which also provides technological support.

“The partnership between these three institutions is rooted in a shared commitment to health,” says Dr Botek.
“Our working hypothesis was that molecular hydrogen could enhance the effectiveness of weight reduction programmes for individuals struggling with overweight or obesity. This idea was based on several promising findings from previous experimental studies—conducted on animals, cultured cells, and even in some human trials.”

Participants drink 500 ml of bottled water three times a day, after which they undergo a thorough round of physical and metabolic testing. The effectiveness of the therapy is assessed through body composition analysis and biochemical markers such as blood glucose levels, lipid profiles, and inflammatory markers.

“So far, no side effects associated with the intake of molecular hydrogen have been observed,” notes Supíková.
“Progress in genetic research, personalised medicine, and novel therapeutic approaches—such as molecular hydrogen—represent the future of obesity treatment. I see great potential in this area for developing safer and more effective therapies tailored to individual patient needs.”

A New Approach to Obesity Treatment

Current research into obesity in the Czech Republic focuses primarily on prevention, diagnosis, and treatment. This study may contribute valuable new insights and methodologies, particularly through its use of innovative therapies.

“Our findings could enrich current treatment strategies,” Supíková concludes.
“In particular, molecular hydrogen may offer a promising and effective new option for addressing adolescent obesity, ultimately contributing to improved public health.”

H2 Global Group
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