Czech Innovation Against Alzheimer’s: H2 Global Group Enters a Key Growth Phase

Czech Innovation Against Alzheimer’s: H2 Global Group Enters a Key Growth Phase

H2 Global Group, together with its subsidiary H2 Medical Technologies, has entered a decisive growth stage following strong recognition at LSI Europe 2025 in London. The group presented its breakthrough approach to preventing and treating neurodegenerative diseases, including Alzheimer’s, confirming its position among global leaders in the MedTech and HealthTech sectors.

At the core of this innovation is a prototype medical device for controlled hydrogen therapy, developed by H2 Medical Technologies. The device is designed for patients with mild cognitive impairment, a condition that often precedes Alzheimer’s. Non-invasive and suitable for both clinical and home use, it is based on a patented method pioneered by a Japanese team led by Professor Shigeo Ohta, co-owner of H2 Global Group. Research indicates that molecular hydrogen can protect brain cells, slow inflammation, and support neuronal metabolism and connectivity.

“Hydrogen is the smallest molecule in the universe, yet it can protect our most valuable assets – memory and independence,” explains Prof. Ohta.

Group founder David Maršálek, who has been developing hydrogen technologies since 2011, adds: “Our mission is to launch the world’s first hydrogen-based medical device for Alzheimer’s prevention and therapy support. With strong scientific evidence, patent protection, and an experienced team, we are positioned to succeed.”

Between 2021 and 2025, H2 Global Group raised over $18M in Seed funding, built a network of 20,000 end-customers and 50+ B2B partners, and exceeded revenues of circa $7.4M. Current transactions value the group at circa $77M.

Now entering Series A, the group plans to raise $25–30 million to fund global expansion into Europe, the U.S., the Middle East, and Africa, complete clinical trials, and secure EU and FDA registrations. Revenue projections forecast growth to nearly $48M by 2029.

The portfolio extends beyond the medical device. H2 Medical Technologies supplies hydrogen generators and therapeutic systems to spas, sports clubs, physiotherapy practices or dental clinics. Its solutions are also approved for veterinary use. In parallel, H2 Pharm develops consumer products such as H2 Premium Water®, H2 Brain®, H2 Forte®, and H2 Dent Care®, which are commercially successful and distributed via e-commerce and a B2B network.

“Such opportunities are rare,” concludes Maršálek. “When future textbooks are written, our investors will say: I was there. Hydrogen is not only energy source but a molecule of lifeconnecting the world. Invest in Hydrogen!”

Source: ap.news.com

Czech MedTech Startup H2 Medical Technologies Unveils World’s First Patented Hydrogen-Based Therapy with the Potential to Target Alzheimer’s Disease

Czech MedTech Startup H2 Medical Technologies Unveils World’s First Patented Hydrogen-Based Therapy with the Potential to Target Alzheimer’s Disease

H2 Medical Technologies, part of the H2 Global Group, has developed the world’s first functional hydrogen-based therapy medical device prototype for clinical trials — aimed at both preventing and treating Alzheimer’s disease.

Today, more than 6.5 million Americans and 50 million people worldwide are living with Alzheimer’s and other forms of dementia. According to the World Health Organization, this number could triple by 2050, placing an immense burden on families and healthcare systems. Despite decades of research, no effective solution has been found — until now.

“This is not another experiment — it is the first technology in the world with the potential to prevent Alzheimer’s disease before it even starts, while supporting those already affected,” says David Marsalek, founder and CEO of H2 Global Group. The company believes its effectiveness will be further confirmed in an upcoming new clinical trial. “Our mission is clear: to turn decades of research into real hope for millions of families around the world. We are part of a strong vision of a society where hydrogen is the molecule of life that connects the world.”

From the Lab to the Global Stage

H2 Global Group will present this breakthrough at LSI Europe 2025 in London, one of the world’s most prestigious MedTech and HealthTech conferences. The project builds on 30+ years of research and patents developed with Professor Shigeo Ohta, a global leader in molecular hydrogen science and co-founder of H2 Global Group.

More Than Medicine: A New Era of Brain Health

While the immediate focus is Alzheimer’s, potential applications extend to neurological disorders, brain regeneration, and healthy aging.

Alongside its medical device, H2 Global Group has launched consumer products such as H2 Premium Water® and H2 Brain®, a world-first two-phase dietary supplement that stimulates molecular hydrogen production through the gut microbiome. The company is also the only certified global manufacturer authorized to use hydrogen-based medical devices in veterinary medicine.

Today, its hydrogen-based solutions are already being adopted by wellness centers, rehabilitation clinics, dental practices, and elite sports organizations across Europe — underscoring the broad potential of the technology.

An Opportunity for Visionary Investors

Until now, the project has been funded primarily by Czech investors. H2 Global Group is now opening the door to U.S. and global partners at a critical growth stage, with EU registration underway and FDA approval next on the horizon — unlocking the world’s largest healthcare market.

The global Alzheimer’s therapeutics market is projected to exceed $20 billion by 2030, with dementia-related costs already surpassing $1 trillion annually. Positioned as the only functional hydrogen-based therapy of its kind, H2 Global Group offers investors a rare first-mover advantage in one of the most urgent and lucrative markets of our time.

Scientists claim: A healthy mouth equals a healthy body and brain

Scientists claim: A healthy mouth equals a healthy body and brain

Oral Health: A Gateway to Whole-Body Wellbeing

Oral health is not merely a matter of a bright smile and fresh breath. A growing body of scientific evidence suggests that bacteria residing in the mouth may have far-reaching consequences for overall health, potentially contributing to serious conditions such as heart disease, Alzheimer’s disease, and even cancer. These findings underline the importance of dental care and the prevention of pathogenic bacteria spreading into the bloodstream and beyond.

What Is the Oral Microbiome?
The oral microbiome is a complex community of microorganisms inhabiting the mouth. This includes bacteria, fungi, viruses, and other microbes that together form a unique ecosystem. While many of these organisms play a beneficial role in maintaining oral health, others can lead to tooth decay, gum disease, and other disorders if they multiply excessively. Maintaining balance within this microbiome is essential—disturbances caused by poor hygiene or an unhealthy diet can lead to inflammation and allow harmful bacteria to enter the bloodstream, potentially affecting the entire body. Supporting a healthy microbiome through proper oral hygiene and balanced nutrition is key to preventing numerous health issues.

From Mouth to Body: Cancer and Other Illnesses
Poor oral hygiene is far more than a cosmetic concern. A study published in the UEG Journal linked poor oral health to an increased risk of liver cancer. Pathogenic oral bacteria can enter the bloodstream and migrate to the liver, potentially causing damage and increasing cancer risk. Likewise, bacteria associated with gum disease have been shown to play a role in the development of cardiovascular disease and diabetes.

How Can You Protect Your Health?
Prevention is essential. Here are several ways to reduce the risk of harmful bacteria spreading from the mouth:

  • Daily dental care: Brushing twice a day, flossing, and using interdental brushes should form part of your everyday routine. Proper cleaning prevents bacterial overgrowth and helps guard against tooth decay and gum disease.

  • Regular dental check-ups and professional cleanings: Early detection and treatment of tooth decay and gum inflammation can help prevent bacterial spread.

  • Supporting a healthy microbiome: A balanced diet rich in vitamins and minerals, reduced sugar intake, and targeted supplements—such as molecular hydrogen—can support gum health and reduce inflammation.

Molecular Hydrogen and Oral Health
One emerging option for promoting oral health is the use of molecular hydrogen, available in products such as hydrogen-rich water or H2 Dent Care. Molecular hydrogen offers antioxidant and anti-inflammatory benefits that may help to reduce oxidative stress in the mouth and support gum regeneration. Regular use can aid in prevention as well as complement treatment of gum disease. Start your oral care routine each morning by rinsing with hydrogen water—before breakfast!

Oral health has a profound impact on the health of the entire body. Caring for your teeth and preventing the spread of bacteria from the mouth are not only vital for avoiding tooth decay but also crucial in protecting the brain, heart, and other essential organs. As science increasingly shows, a healthy mouth is the foundation of a healthy life.

Molecular Hydrogen in the Dentist’s Chair

Molecular Hydrogen in the Dentist’s Chair

Experienced Dentist Dr Lubomír Beran: “Hydrogen-Based Therapies Truly Make a Difference”

Dr Lubomír Beran, an experienced dental surgeon and clinical advisor to the private AJNA dental clinic and emergency service in Ostrava, welcomes every innovation in his field with open arms. When he first learnt about the effects of molecular hydrogen on the human body, he didn’t hesitate to try it himself—and soon after began applying it in patient care at his clinic. His enthusiasm is unmistakable. “I can see and feel for myself that these therapies are outstanding,” he says.

With over 40 years of experience in oral surgery and implantology, Dr Beran currently runs a successful dental and aesthetic centre in Velký Třebešov. Known for his professional and compassionate approach, the 72-year-old dentist remains as passionate about dentistry as ever. “People ask why I haven’t retired yet—why I’m not relaxing somewhere,” he laughs. “I tell them, are you mad? I’m only halfway through my life! I’m planning to live to 150! And I know I will! I keep discovering new things I want to do, and that keeps me going. Telling people this gives me energy—it’s what drives me forward, even though my body is already worn out.”

Ostrava’s Dental Reality: A Neglected Smile
When Dr Beran began treating patients in Ostrava, he was taken aback by the poor state of many people’s teeth. Often, he would guess a patient’s age to be 20 years older than their medical records suggested—simply by looking at their oral condition. “The most common issue is severe neglect. People only come to us when the pain becomes unbearable and they manage to save up some money. Very few arrive with just two or three minor problems—those patients bring me real joy.”

Unfortunately, many new patients at the AJNA clinic hadn’t seen a dentist in up to seven years. Often, they only discover their previous dentist has retired or removed their medical file once the pain begins. Suddenly, urgent dental care is needed, and they’re willing to invest to relieve the pain and, ideally, save their teeth. However, as Dr Beran points out, years of neglect usually leave a devastating mark. “When we do a CT scan, what we find is often shocking. In most cases, two-thirds of the teeth have to be removed. Some can be saved, or we might find just one or two healthy teeth left—at that point, it’s not worth keeping them. So, we extract everything, provide temporary dentures, and after a healing period, we proceed with prosthetic treatment.”

Hydrogen Therapy for Recovery
It is during this post-surgical recovery phase that patients are introduced to molecular hydrogen. “If we agree to remove, say, an entire jaw, we’re left with a large wound. This is where hydrogen makes a huge difference. I’m absolutely convinced of its benefits. It significantly accelerates healing and, importantly, reduces pain. Patients tell us the very next day that they barely felt any discomfort. That’s remarkable—it’s a single application and the effect is clear.”

Dr Beran praises hydrogen-based therapies and plans to incorporate them even more widely in his practice. “I can truly feel their effectiveness. We’re actively testing them with patients. We have a dental hygienist here who’s equipped with a full range of hydrogen products. She explains everything to patients and, if they’re interested, also supplies the products. After more complex procedures—like wisdom tooth extractions—we send patients to her. They then relax for half an hour with music while inhaling molecular hydrogen,” he adds with delight.

“We’re still in the early stages, but I’m considering setting up a dedicated hydrogen therapy room for patients after treatments from all our clinics. After all, any dental procedure is stressful. Why not offer a space to relax and inhale hydrogen?” he reflects. Stress, he explains, is a key factor in the production of free radicals, and current research shows molecular hydrogen helps balance those with beneficial antioxidants. “I was introduced to hydrogen through our partner organisation at H2 Global Group, with whom we’re working on several fascinating joint projects aimed at supporting patient health more effectively. I learnt that molecular hydrogen has a significantly positive impact on the nervous system, helps rejuvenate the body, strengthens the immune system, and visibly aids in managing stress.”

The Future of Dentistry—Near and Far
Thanks to innovations like molecular hydrogen, Dr Beran believes he’ll be able to keep helping patients for another 50 years. “Modern life is incredibly hectic. People sleep poorly, eat badly, and that takes a toll on the body. Luckily, we now have people bringing forward ways to support health not just with pharmaceuticals—many of which cause side effects that require further medication—but with natural and supportive alternatives. Hydrogen is one of them.”

Dr Beran is also dedicating much of his time, alongside a team of fellow dentists, to a project aimed at opening up to 300 new dental practices across the Czech Republic—ensuring that everyone has access to their own dentist and to high-quality, insurance-covered care. He and his colleagues have also succeeded in reviving a tradition in the Jeseník region: providing schoolchildren with regular dental care directly in schools. “It was a nightmare in terms of legislation—getting all the permissions just to examine a child. But we did it, and I’m genuinely proud of that,” he concludes.

The first hydrogen dental office

The first hydrogen dental office

AJNA Clinic in Ostrava: The World’s First Dental Practice to Introduce Molecular Hydrogen in Post-Treatment Recovery

Patients at the AJNA Dental Clinic in Ostrava are the first in the world to experience the benefits of molecular hydrogen directly at their dentist’s office as part of post-treatment care. The clinic’s leadership has partnered with Ostrava-based company H2 Global Group to implement a pioneering solution—introducing unique hydrogen-based devices and products to support patients’ recovery.

“Available research shows that molecular hydrogen can accelerate healing and reduce pain. That’s precisely what we want to offer clients at AJNA. And this is just the beginning,” says David Maršálek, President of H2 Global Group, whose company has patented this breakthrough innovation.

Making Dentistry Less Stressful
Drilling, extractions, implants—despite the advancements in modern dentistry, many still find dental treatments stressful and painful. “We are constantly looking for ways to make dental visits more pleasant, to ease pain, and to speed up wound healing after extractions or other procedures,” explains Dr Lubomír Beran, the clinic’s medical advisor and a highly experienced dentist.

After reading several scientific studies on molecular hydrogen, Dr Beran decided to try it for himself. He was pleasantly surprised by how energised he felt. “I’m 72 and have no plans to retire. But I do occasionally feel tired. Since I started inhaling hydrogen and drinking hydrogen-enriched water regularly, I’ve felt significantly better. That’s why I now offer it to all our patients after major procedures,” he says.

Partnering with a Global Hydrogen Leader
Dr Beran partnered with H2 Global Group—a global leader in hydrogen technology across health, spa & wellness, beauty, sports, agriculture and veterinary sectors. “Following discussions with Dr Beran, we supplied the AJNA clinic with our H2 Hydrogen Generator i300, the H2 Professional Water Generator, and the 6-in-1 Multifunctional Wellness Hydrogen Generator. These devices allow patients not only to inhale hydrogen but also to drink hydrogen-rich water. We also recommend H2 Dent Care tablets, which release molecular hydrogen upon contact with saliva. This supports healing and offers strong antioxidant effects,” explains David Maršálek.

MUDr. Lubomír Beran

Hydrogen in Dental Practice
In practice, after their dental procedure is complete, patients are guided to the hygiene room. There, they are comfortably seated, given nasal cannulas, and gently immersed in relaxing music while inhaling molecular hydrogen. They are also offered hydrogen-rich water during a 30-minute relaxation session.

Dr Lubomír Beran
“We’re only at the beginning,” Dr Beran says, “but I’m planning to create a dedicated recovery room where patients from all our clinics can come to relax and inhale hydrogen post-treatment.” He explains that stress is one of the main causes of oxidative damage due to free radicals. According to current scientific findings, molecular hydrogen helps restore balance by neutralising free radicals with beneficial antioxidants.

“I was introduced to hydrogen through our partnership with H2 Global Group, with whom we are now working on exciting joint projects to improve patient care. From them, I learnt about hydrogen’s wide-reaching effects on the body. It helps to regulate the nervous system, rejuvenate the body, support immune function, and tangibly reduce stress. The feedback from our patients so far has been excellent—especially in terms of healing support. Together, we have now developed a unique method for applying hydrogen directly to the teeth and gums, which we’ve patented,” he adds.

A Glimpse into the Future of Dental Care
According to David Maršálek, dentistry is just the beginning. “Our devices and products are increasingly used in spas, wellness centres, and beauty salons, where hydrogen acts as a catalyst—enhancing and accelerating the effects of conventional treatments. We’re being approached not just by dentists and spa operators, but also by doctors from various medical fields who want to integrate our unique hydrogen application know-how into their practices.

It won’t be long before hydrogen therapy becomes a standard component of patient care across many medical disciplines—just as it already is in Japan. Molecular hydrogen can serve as a supportive treatment alongside conventional therapies, a preventative tool, or a recovery aid,” concludes Maršálek.

H2 Global Group
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