Oncology

Humans

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Protective Effect of Hydrogen-Rich Water on Liver Function of Colorectal Cancer Patients Treated with mFOLFOX6 Chemotherapy

Authors:
Yang, Q.; Ji, G.; Pan, R.; Zhao, Y.; Yan, P.
Source: Molecular and Clinical Oncology, Volume 7, Issue 5 (2017)
DOI: 10.3892/mco.2017.1409

Objective

This study aimed to explore the protective effect of hydrogen-rich water (HRW) on liver function in colorectal cancer (CRC) patients undergoing mFOLFOX6 chemotherapy, a regimen known to impair hepatic function.

Methods

A controlled, randomized, single-blind clinical trial was conducted from June 2010 to February 2016 at the Oncology Department of Taishan Hospital (Taian, China).

  • Total patients enrolled: 152

  • Eligible for inclusion: 146

  • Randomized: 144 patients → HRW group (n = 80), placebo group (n = 64)

  • Analyzed in final results: 76 (HRW), 60 (placebo)

Changes in liver function markers were measured before and after chemotherapy:

  • ALT (Alanine aminotransferase)

  • AST (Aspartate aminotransferase)

  • Alkaline phosphatase

  • Indirect bilirubin (IBIL)

  • Direct bilirubin

Elevated ALT, AST, and IBIL were considered indicators of liver damage from mFOLFOX6 chemotherapy.

Results

  • The HRW group showed no significant changes in liver function before and after treatment.

  • The placebo group exhibited significantly increased levels of ALT, AST, and IBIL, indicating chemotherapy-induced liver damage.

Conclusion

Hydrogen-rich water appears to alleviate liver impairment associated with mFOLFOX6 chemotherapy in CRC patients. This suggests a hepatoprotective effect of molecular hydrogen in oncological care

Animals

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Radio-Protective Effect of Hydrogen-Rich Water Combined with Amifostine in Mice

Authors:
Qin, X.; Yin, J.; Li, J.; An, Q.; Wen, J.; Niu, Q.
Source: International Journal of Radiation Research, Volume 14, Issue 2 (2016)
URL: http://ijrr.com/article-1-1714-en.html

Background

Hydrogen has been shown to selectively reduce hydroxyl radicals, the main cause of ionizing radiation-induced damage.
Amifostine (AM) is the only radioprotective drug approved by the U.S. FDA for clinical use during radiotherapy.

Objective

This study aimed to investigate the combined radioprotective effect of hydrogen-rich water (HRW) and amifostine (AM) in mice.

Methods

  • Subjects: Male ICR mice

  • Treatment: Mice were treated either with:

    • HRW (administered intragastrically),

    • AM (administered intraperitoneally),

    • or a combination of both

  • Timing: 30 minutes before total-body irradiation with 9.0 Gy of 60Co gamma rays (dose rate: 0.96 Gy/min)

The following were monitored:

  • 30-day survival rate

  • Body weight

  • Hematologic and clinical chemistry parameters

  • Bone marrow nucleated cells

Results

  • The combination of HRW + AM significantly increased 30-day survival and improved body weight, with 2× better results than either HRW or AM alone.

  • Hematologic and biochemical tests also confirmed enhanced recovery of the hematopoietic system and reduction of radiation-induced toxicity in the combination group compared to controls.

Conclusion

The findings suggest that co-administration of hydrogen-rich water and amifostine can enhance the protective effects during radiation exposure and may improve the therapeutic window of radiotherapy.

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